By Michael W. Adler,Simon G. Edwards,Robert F. Miller, et al.John Wiley & Sons, Inc.|Wiley||BMJ BooksAdult NonfictionMedical, Reference, Text BookLanguage(s): EnglishOn sale date: 23.05.2012Street date: 30.04.2012
An authoritative consultant to the epidemiology, prevalence, trying out and prognosis and administration of HIV and AIDS.
From a world specialist editor and contributor group, this new 6th variation contains accelerated insurance of HIV trying out, evaluation and regimen stick to up and new chapters outlining difficult stipulations linked to HIV and AIDS. Prevention recommendations, early analysis and antiretroviral medicinal drugs and pharmacotherapy are lined intimately in addition to little ones and girls with HIV. It additionally addresses key mental and psychological overall healthiness concerns, sufferer views and the position of sufferer engagement.
As wisdom into the sickness grows and significant advances in HIV remedy see extra humans residing with HIV in the neighborhood, the ABC of HIV and AIDS, 6e offers transparent sensible assistance for common practitioners, medical institution medical professionals, nurses, scientific scholars, counsellors, allied medical examiners and somebody operating and taking good care of sufferers with HIV and AIDS.
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Extra resources for ABC of HIV and AIDS
LIA uses a similar principle to WB but employs recombinant HIV antigens and synthetic peptides applied on nitrocellulose strips, which improves standardization and reduces background reactivity. The viral antigens include gp160, gp120, p66, p55, p51, gp41, p31, p24, p17 and p15, and established criteria are used for the interpretation of results. Rapid point-of-care HIV screening tests Rapid, near-patient HIV screening tests have been developed in order to facilitate access to HIV testing, for example where laboratory infrastructure is limited, and to promote patient acceptability by facilitating and shortening the testing procedure.
Lancet 2010;375:1014–1028. Chapter 2 Immunology of HIV-1 Infection M. Noursadeghi and D. Pillay University College London, London, UK Overview During transmission of infection, HIV-1 interacts with macrophages and dendritic cells at the site of inoculation, leading to transfer of virus to CD4 T cells within lymph nodes, where the majority of viral replication occurs HIV-1 replication induces antiviral antibody and cytotoxic T-cell responses that help to control HIV replication during primary infection HIV-1 displays various mechanisms of immune evasion that help to prevent its eradication despite antiviral immune responses HIV-1 induces widespread dysregulated immune activation that causes depletion of circulating CD4 T cells by sequestration of memory T cells within lymph nodes and exhaustion of the naïve T-cell pool Immunodeficiency in AIDS is due to multiple mechanisms, including abnormalities of macrophage, dendritic cell, B cell and CD8 T-cell function as well the effects on CD4 T cells Introduction The interactions of HIV-1 with the immune system contribute extensively to the pathogenesis of AIDS.
G. needlestick injury) or in untested pregnant women presenting during labour, in order to inform prophylactic measures. 2). 2 Point-of-care HIV antibody screening tests. Advantages Disadvantages Rapid, provide results <30 min Expensive Detect antibodies against HIV-1 (groups M and O) and HIV-2 Reduced sensitivity in early infection compared with laboratory-based assays Require simple equipment Prone to operator errors Easy to perform and interpret Subjective interpretation of results Avoid venopuncture May give false positive results Include a positive control Reactive results require laboratory confirmation Perform well compared with laboratory methods Quality assurance complex to arrange The assays have good specificity and sensitivity in established HIV infection.