Download Aldo-Keto Reductases and Toxicant Metabolism by Trevor M. Penning, J. Mark Petrash PDF

By Trevor M. Penning, J. Mark Petrash

content material: part 1: basic assessment ; 1. advent and review of the Aldo-Keto Reductase (AKR) Superfamily ; part 2: AKRS AND ENDOGENOUS TOXICANTS ; 2. Aldo-Keto Reductase-Catalyzed Detoxication of Endogenous Aldehydes linked to Diabetic problems ; three. Aldose Reductase Detoxifies Lipid Aldehydes and Their Glutathione Conjugates ; four. position of Aldose Reductase within the detoxing of Oxidized Phospholipids ; part three: AKRS AND EXOGENOUS TOXICANTS: TOBACCO similar cancer agents ; five. Competing Roles of Reductases within the cleansing of the Tobacco-Specific Nitrosamine Ketone NNK ; 6. Aldo-Keto Reductases and the Metabolic Activation of Polycyclic fragrant Hydrocarbons ; 7. Molecular Cloning and Characterization of Dihydrodiol Dehydrogenase from Mouse ; eight effective Synthesis of the lively Metabolites of Carcinogenic Polycyclic fragrant Hydrocarbons ; nine. Chemistry of PAH o-Quinones Generated through the AKR Pathway of PAH Activation ; 10. research of Etheno-2'-Deoxyguanosine Adducts as Dosimeters of AKR Mediated Oxidative rigidity ; part four: AKRS AND EXOGENOUS TOXICANTS: MYCOTOXINS, ALDEHYDES AND KETONES ; eleven. Aflatoxin Aldehyde Reductases ; 12. Competing Reactions of Aflatoxin B1-Dialdehyde: Enzymatic relief vs Adduction with Lysine ; thirteen. using mammalian telephone strains to enquire the position of aldo-keto reductases within the detoxication of aldehydes and ketones ; part five: AKRS, the tension reaction AND phone SIGNALING ; 14. Aldose Reductase and the tension reaction ; 15. Aldose Reductase Regulates Reactive Oxygen Species Mediated-Inflammatory indications ; sixteen. Aldo-Keto Reductases within the tension reaction of the Budding Yeast Saccharomyces cerevisiae

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ACS Symposium Series; American Chemical Society: Washington, DC, 2003. 28 the aldehyde is an oxidized carbon. Thus, glycoaldehyde, glyoxal and glyoxylate are much better substrates than acetaldehyde, and acrolein, glyceraldehyde and MeG are much better substrates than propionaldehyde. This difference is even greater than suggested by the k JK values when one considers that the aldehyde functional groups of these aldehydes are highly hydrated compared to acetaldehyde and propionaldehyde, leaving the concentration offreealdehyde that i?

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